Acute Myelogenous Leukemias with Recurrent Cytogenetic Abnormalities

Cute Myelogenous Leukemias with Recurrent Cytogenetic Abnormalities

Definition

This WHO group of Acute Myelogenous Leukemias is characterized by recurrent genetic abnormalities. The abnormalities are generally balanced translocations and have a high ratio  of complete remission and favorable prognosis. 

Sample Cases

Click here for instructions on how to download the free FCS Express Reader to view and manipulate the sample cases.

Categories

The following are recurring cytogenetic abnormalities seen in AML:

• Acute myeloid leukemia with t(8;21)(q22;q22); (AML1/ETO)
• Acute myelid leukemia with inv(16)(p13q22) or t(16;16)(p13q22); (CBFB/MYH11)
• Acute promyelocytic leukemia (AML with t(15;17)(q22;q12); (PML/RARa)
• Acute meyeloid leukemia with 11q23 (MLL) abnormalities

 Many of these genetic abnormalities are detected by reverse polymerase chain reaction (RT-PCR) which has a higher vity of ( X 10 5) than conventional cytogenetics (1 X 10 2)

Morphology and cytochemistry

Immunophenotyping

Other relevant tests

Genetics

Certain cytogenetic abnormalities are associated with very good outcomes (for example, the (15;17) translocation in acute promyelocytic leukemia). About half of AML patients have "normal" cytogenetics; they fall into an intermediate risk group. A number of other cytogenetic abnormalities are known to associate with a poor prognosis and a high risk of relapse after treatment

Subclassification

Flow Diagnosis

References

Contributors to this page

g.